Sunday, October 6, 2019
Tort Law Essay Example | Topics and Well Written Essays - 2000 words
Tort Law - Essay Example This analysis will take into account the various damages that may be available to the plaintiffs according to the breaches of the Civil Code and tort in Common Law. The analysis of liability will therefore be pursued in a manner that will ensure that people that were harmed by negligence and battery will be justly compensated and the persons who breached the law are punished. Liability The Company Under common law, the company may be liable for battery since the chemicals that were ingested by the townspeople and the children originated from the company. The company is guilty since the elements of battery are present in the case. Offensive contact is proved by the coming into contact of the people and the chemicals through water, which resulted into injury in death. There is a lack of consent on the part of the townspeople on the dumping of the chemicals in the water. Additionally the company does not have the privilege of dumping toxic wastes in the public systems. The case for batt ery however lacks the element of intent since the company has proved that it educated its workers on proper disposal and as such not intended to careless dump of its chemical waste. In Garratt v. Dailey [1955] 2 d 46 [HL]1 the plaintiff brought battery charges against the plaintiff a five year old of pulling the chair she was about to sit on causing her injury. The issue was in question was whether battery charges are improvable since intent of the child is not easily proven. The company is therefore not liable for battery. The company may also be sued on negligence since it is because of its workers actions that the injury to the townspeople and children occurred. The three elements of negligence; duty of care, breach and proof of injury are all present in this instance. Duty of care entails that the company owes it to the community to be careful in the disposal of waste. A breach would entail the non-adherence to such care, which would result to an injury. This exemplified by the case of Talmage v Smith, 101 Mich. 370, 374, 59 N.W. 656 2 in which it was held that liability is proved upon the consideration of a reasonable manââ¬â¢s precautions towards the happening of an injury. The duty of care was breached when the company allowed its chemicals to infect the public water system resulting into injury for the townspeople3. The company did not ensure the proper disposal of chemicals by its staff and as such liable for negligence. Under strict liability, the company may argue that it was not aware that the tanks might leak chemicals into the system. It might also be argued that the company had trained its staff with regard to the handling of such chemicals. Strict liability usually has only one element; liability arises from the happening of an injurious event. Under strict liability there is no need top prove intent such as in battery but simply that injury occurred. Under strict liability doctrine, the company is liable in that even though it took all prec autions, under common law, it is still liable in tort. A good example of this is the case of Cambridge Waster Company v. Eastern Counties Leather [1994] 2 AC 2643 (HL) the rule is that even as people have a right of enjoyment of land, the keeping of anything on the land will result to liability if it escapes from the land4. The UAE Civil Code does not
Friday, October 4, 2019
Business accounting - Lampeter Builder's Merchants Essay
Business accounting - Lampeter Builder's Merchants - Essay Example Vehicle running expenses 44,000 Electricity 3,000 Insurance 15,000 Stationery 2,000 208,000 Net profit 540,000 (2) Profit and Loss Statement LAMPETERS BUILDERS MANAGEMENT BALANCE SHEET AS AT MARCH 31, 2011 Amount in ? Non-Current Assets Fixed Assets (Cost) 200,000 Accumulated Depreciation (100,000) Fixed Assets (WDV) 100,000 Current Assets Trade debtors 18,000 Bank (9,000) Closing Stock 478,000 Total Assets 587,000 Current Liabilities Trade creditors 43,000 Capital 28,000 Drawings (24,000) Profit for the year 540,000 Total Equity and Capital 587,000 (3) Value Added Taxation Research The prime resource for research was the website ââ¬ËHM Revenue and Customsââ¬â¢ Planning and ordering What are the prevailing VAT rates in UK What rates are applicable on the business that the company is currently engaged in What are the methods and procedure of filing the VAT returns How the VAT is calculated What are the deadlines for submission of the return Presentation VAT is applicable on diff erent rate depending on the type of Goods and services offered by the company. In addition, there are some goods and services that are exempted from VAT. The VAT rates are divided into three segments Standard Rate 20 per cent Reduced Rate 5 per cent Zero Rate 0 per cent [1] Since the Company, Lampeter Buildersââ¬â¢ Merchants is involved in the construction and material business, the following rates are applicable on the company Type of work VAT rate Construction of a new house or flat zero Converting a building into a house or flat reduced rate Renovating or altering an empty house or flat reduced rate Supplying and installing certain mobility aids for elderly people reduced rate Supplying and installing certain energy saving materials and equipment reduced rate Supplying and installing certain...VAT is applicable on different rate depending on the type of Goods and services offered by the company. In addition, there are some goods and services that are exempted from VAT. The VAT rates are divided into three segments Standard Rate 20 per cent Reduced Rate 5 per cent Zero Rate 0 per cent [1] Since the Company, Lampeter Buildersââ¬â¢ Merchants is involved in the construction and material business, the following rates are applicable on the company At the end of every three months, the company already registered for VAT needs, to file a quarterly VAT return. The return can be filed either electronically or through paper returns. The returns, after properly completing are then sent to the following address
Woodlands Community Center Corporation Case Analysis Essay Example for Free
Woodlands Community Center Corporation Case Analysis Essay The Woodland Community Center Cooperation (WCCC) had been established in 1926 by a social worker who thought that Woodland, an East Coast seaport town, would benefit from a variety of social and human services. Alain Yates, the longest serving executive director, was a long standing icon in the organization for many years, and due to a mixture of longevity and assertion, had shaped the organizational culture of the agency during his time of leadership. He had established a culture that didnââ¬â¢t necessarily reward what would be considered the ââ¬Å"normâ⬠; such has hard work and excellence. Instead he rewarded seniority and loyalty to the organization, and above all, loyalty to him. Employees advanced through becoming Yatesââ¬â¢ ââ¬Å"petâ⬠employees, and received perks such as parking and expensive trips to out of state conferences. This preferential behavior created a rift within the organization and its employees. If people complained, then they were slowly trickled out by Yates, and replaced by more loyal employees. After 25 years of service, Yates retired, and while naming his suggestion for a successor, the board quickly and surprisingly undermined his influence and hired Fred Chambers. Fred was a man of substance and experience, and they needed someone to come in and not only change he organizational culture, but improve it. Fredââ¬â¢s wife had advised against taking this appointment, yet Fred took on the challenge, and in this case analysis we meet Fred just as he is beginning to take in the breadth of this challenge. Organization culture at Woodland Community Center Corporation was based on the values imposed by Yates. He believed that ââ¬Å"seniority was sacrosanct, and neither creativity nor hard work replaced itâ⬠(McShane 539). This created a dominant organizational culture that believed that loyalty to Alan Yates was all that mattered, considering that the employees enjoyed a secure work environment as few employees ere fired for poor work ethic. ââ¬Å"The key to employee survival and its attendant rewards was loyalty, not competency. Furthermore, loyalty was the sole way to advance in the agency or to receive pay increases for the agencyââ¬â¢s over 100 employeesâ⬠(McShane 539). As Yates continued his tenure, the organization was becoming more incestuous and a breeding ground for a groupthink mentality. ââ¬Å"the agency had one characteristic in common: they swore undying loyalty to Yatesâ⬠(McShane 539). Although Yates dominated the organizational culture with his own values, there was still a certain subculture that opposed him. The employees who were not impressed by Yates created the counterculture considering that they directly opposed the dominant values in the organization. They tried to maintain the organizationââ¬â¢s standards of performance and ethical behavior as one employee stated ââ¬Å"we are committed to working for the betterment of the agency and its clients, and we will stay despite Yates preferential treatment of pet employeesâ⬠(McShane 539). They tried to maintain the values that kept the firm aligned with the needs of the society and other stakeholders. The subculture opposed to Yates could have been helpful in changing the dominant culture upon his retirement, but the executive director was able to suppress it over time. Employees that were part of the subculture began to retire of slowly trickle out because they could not longer tolerate ââ¬Å"employment injusticesâ⬠(McShane 540). Each employee that left would then be replaced by a loyal Yates supporter, which made in the more difficult for the New Executive Director Fred Chambers to change contaminated culture. In reading about organizational cultures, our text places images of strong, adaptive cultures. Cultures where the employees strive to improve customer focus and carry on long standing traditions that have carried the success of the companies. However, in this weekââ¬â¢s case study, we find a great example of what a weak organizational structure is. Alan Yates has instilled a weak organizational culture during his tenure at WCCC. While at WCCC Alan Yates has allowed an organization culture that has slide away from customer services and has not become adaptive. The organizational culture has become one were loyalty and servitude has more value than ability and knowledge. ââ¬Å"The key to employee survival and its attendant rewards was loyalty, not competencyâ⬠(McShane 539). From this quote, it is clear to see that Alan Yates has created a culture of ââ¬Å"yesâ⬠people, loyal to him and unable to correctly serve their client base. Furthermore, the organizational culture is being eroded as ââ¬Å"adaptiveâ⬠employees leave the company (McShane 467). As stated before, the organizational culture is further weakened by Mr. Yates as more experienced and ââ¬Å"adaptiveâ⬠employees are alienated and replaced by ââ¬Å"in-crowdâ⬠employees. As the experienced employees leave, they erode the company by taking away many of the ââ¬Å"rituals, legends and ceremoniesâ⬠of the company (McShane 464). As the more experienced employees leave the company, many of the rituals, legends and ceremonies that had made WCCC successful will be lost, as they will be lost in the transition to new employees. The text also describes the three important functions of a strong culture, ââ¬Å"Control system, Social glue and Sense makingâ⬠(McShane 466). Again, it is interesting to see how a weak organizational culture works. Looking at WCCCââ¬â¢s control system with Mr. Yates, it is evident that a ââ¬Å"deeply embedded form of social control that influences employee decisions and behaviorâ⬠is present in the company (McShane 466). The only problem is the control system is too strong and influential. An example from the case study cites ââ¬Å"Both, regardless of how they arrived at the agency, had one characteristic in common: They swore loyalty to Yatesâ⬠(McShane 540). As more employees became loyal to Yates, the control system became to strong. The weakest part of the culture is tied to the ââ¬Å"social glueâ⬠(McShane 466). ââ¬Å"Organizational culture is the ââ¬Å"social glueâ⬠that bonds people together and makes them feel part of the organizational experienceâ⬠(McShane 466). The case study talks of a ââ¬Å"growing riftâ⬠among employees that are loyal or not to Yates (McShane 539). The organizational culture suffers from a split in the employees as more experienced employees feel left out by Yates. This effectively shows a lack of ââ¬Å"social glueâ⬠within the organizational culture of WCCC. Overall, it is easy to see that the organizational culture during Mr. Yates tenure has been significantly decreased at WCCC. The company lacks any ââ¬Å"social glueâ⬠that could improve employee moral and it further harmed by the overbearing control of Mr. Yates. During his 25 year stay at WCCC, Mr. Yates has turned the organizational culture to nothing more than a ââ¬Å"yesâ⬠culture. Fred Chambers is well aware how much organizational change is needed at the Woodland Community Center Corporation. There are both driving and restraining forces for change found in this case which will make Fred Chambersââ¬â¢ new position of executive director a difficult one. It is his goal to effectively manage these forces in order to successfully point the Woodland Community Center Corporation into a new direction. Alain Yates left a divided and unhappy workforce for Fred Chambers to fix. ââ¬Å"Yates had encouraged policies of ââ¬Å"double standardsâ⬠that de-motivated some long-term and industrious agency employees. (McShane 532) Yates had his favorite employees and those who were within his inner circle. Certain people had reserved parking spots, whereas others had to park far away and take the long walk to the building from their car in inclement weather. Others were not allowed to go to training sessions to further their knowledge while they stood buy and watched certain employees go to expensive out of state conferences. ââ¬Å"Yatesââ¬â¢s actions resulted in a small but noticeable agency fissure that led to a growing rift between employees who sought to excel and those who just got by on their loyalty. ( McShane 532) Employees wanted to be rewarded for their work ethic and not their loyalty. People would no longer go the extra mile if they werenââ¬â¢t in Yatesââ¬â¢s inner circle. This is a definite driving force for change. Fair and equal treatment needs to be implemented throughout the corporation. Despite all of the negative practices that Alain Yates implemented, those employees who were not treated fairly did not leave WCCC. They were paid very well and had a drive to help the clients that the agency worked with. Eventually, most of these employees left and were replaced by loyal supporters of Yates. Chambers needs to drive home that sense of loyalty to Woodland Community Center Corporationââ¬â¢s clients to those employees who remained despite not being in Yatesââ¬â¢s inner circle. These employees need to still be competitively paid and reassured that their work will be appreciated. On the other hand, most of the employees of WCCC are loyal to Alain Yates and Fred Chambers will have an up road battle to convince the supporters of Yates that he will do a great job. Fred Chambers will most likely face many restraining forces for change. In some situations employees may be worried about the consequences of change, such as how the new conditions will take away their power and status. In other situations, employees show resistance because of concerns about the process of change itself, such as the effort required to break old habits and learn new skills. â⬠(McShane 490) Fred Chambers needs to set a standard of equality. Yatesââ¬â¢s inner circle no longer exists, and these employees need to know that they have to step up to the challenge and prove themselves. One resistance to change is the fear of the unknown. Employees do not know what is in stored for them. People resist change out of worry that they cannot adjust to the new work requirements. â⬠(McShane 491) Workers might not have performed up to their potential because they were favored by Yates. Another resistance to change is when a routine is broken. ââ¬Å"This means employees need to abandon behavioral routines that are no longer appropriate. â⬠(McShane 491) Employees will not be used to the style of Fred Chambers. He most likely wants to do things differently, and they will have to adjust accordingly. Fred Chambers needs to approach organizational change from an evolutionary perspective. Alain Yates had run the WCCC for twenty five years. Many of the employees had been there for a long time and have been accustomed to his leadership style. Fred Chambers needs to implement certain changes right away, but at the same time, one does not want to rock the boat too much. He must create a more equal and level playing field for all employees. Chambers must gain the trust of all his workers and prove to them that he is dedicated to them, the organization, and most importantly, the companyââ¬â¢s clients. By being too aggressive in his actions, Chambers will not give off a good impression and turn a lot of people off. He needs to use tact and apply his experiences to his new position. Over the next year or two, employees will realize that they are valued by the work they do and not by the personal connections they may have. Fred Chambers is required to make a lot of changes, and to convince a staff who has been conditioned to be loyal to a man who is no longer at the helm of the ship. Additionally, it seems that decisions had been made that werenââ¬â¢t pro-business, only pro-Yates. These will need to be reversed, which will naturally result in push back from the employees who had had these perks-who wants to give up a good parking spot? We believe that change really needs to begin at the bottom with the employees. First, Chambers should hold a meeting, outlining some initial changes within the organization, as well as explaining what in the world would make the board make such decisions. Providing some transparency at the top would help build some trust from employees. It would be important to not dwell on the past, but to focus on the future. He should talk about how important it is that people focus on the increased productivity and services of the organization, as opposed to the past which was riddled with preferential treatment and poor business decisions. The opportunities here far outweigh negativity brought by employees entrenched in the previous culture. This is an opportunity to have the employees really concentrate and recommit to the mission and vision of the organization. Perhaps he could do a workshop outlining goals, and the mission/vision of the organization. The future of the organizations fiscal and organizational health lies in Fredââ¬â¢s ability to gain the trust of the employees and then steer them towards good work product output, expectations of advancement when warranted through good work, and perhaps some leaner times financially, if there need to be lay offs. Fred needs to make the employees feel as though they belong to an organization who works well together. Create a sense of belonging. This is how Yates succeeded in turning the culture in his way, and it wonââ¬â¢t be too difficult to do the same. Chambers also has a leg up when it comes to cost cutting. He will be able to outline to the entire organization that expenses such as trips, far away conferences and training will not be available to anyone, regardless of the reason or connection. This will allow people to see that Chambers will not play favorites, which has been an issue of concern in the past. It also tells the employees that there are financial concerns, and they should be cognizant of where they spend money. While there will be some initial push back, Chambers can and we believe will succeed. He has experience in running non profits; he is a seasoned professional in dealing with non-profit staff. Chambers should approach this challenge with the belief that what one poor leader had done can be undone by a strong leader with a good understanding of the culture, the people, and a strong commitment to the success of the organization.
Thursday, October 3, 2019
Tetrodotoxin And The Threat Of Bioterrorism Biology Essay
Tetrodotoxin And The Threat Of Bioterrorism Biology Essay The threat of bioterrorism remains a reality worldwide, although of low probability, an attack would be a high-consequence event. Microbes are available to individuals with appropriate contacts and even many low-grade bacterial pathogens can severely affect health. Toxins provide bacteria with a system of defense that is often detrimental to humans and their versatility makes them potential tools of bioterrorism. It should be remembered that the aim of terrorism is not always to kill but rather to strike fear into peoples lives. Importantly, no state can ever be fully prepared for a response and it is probable that no state ever could be. It is for this reason that biological agents are so attractive as weapons. (British Journal of Biomedical Science, 2005) Deserving of a closer look as a potential weapon of bioterrorism and as a threat to public health and safety is tetrodotoxin. Tetrodotoxin (TTX) is a potent marine neurotoxin, named after the order of fish from which it is most commonly associated, the Tetrodoniformes (tetras four and odontos-tooth), or the tetraodon puffer fish. The tetraodon puffers are equipped with four large teeth which are nearly fused, forming a beak-like structure used for cracking mollusks and other invertebrates, as well as for scraping corals and general reef grazing. (Florida State University, January, 2002) According to the New York Times, first isolated from the puffer fish, tetrodotoxin is among the most potent toxins known. It is 100 times as toxic by weight as potassium cyanide two milligrams can kill an adult human and it is not destroyed by cooking. Tetrodotoxin is found in more than just marine creatures. It is present in high concentrations in the skin of certain newts in North American and Japan, and in several kinds of frogs in Central and South America and Banglaesh. (New York Times Science, December, 2009) The flesh of the puffer fish (i.e. fugu) is considered a delicacy in Japan. It is prepared by chefs specially trained and certified by the government to prepare the flesh free of the toxic liver, gonads and skin. Despite these precautions, many cases of tetrodotoxin poisoning are reported each year in patients ingesting fugu. (Medscape CDC Commentary Series, October, 2009) From 1974 through 1983 there 646 reported cases of fugu (puffer fish) poisoning in Japan, with 179 fatalities. Estimates as high as 200 cases per year with mortality approaching 50% have been reported. (Florida State University, January, 2002) Interestingly while tetrodotoxin is found in several different branches of the animal kingdom, the tetrodotoxin found in each of these creatures is identical unlike the venoms produced by snakes and scorpions which are made up of different kinds of toxins particular to that species. The evidence suggests that these animals do make the toxin themselves. (New York Times Science, December, 2009) The toxin itself appears to be made by relatively common marine bacteria, specifically Pseudoalteromonas haloplanktis tetraodonis, which associates with these animals. Validating this theory when puffer fish are raised in aquariums with filtered, bacteria-free water, they are non-toxic and the same results are achieved when Japanese newts or Panamanian frogs are raised on special diets they lose their toxicity. These experiments validate the theory that these toxic animals obtain the toxin from the food chain. Several species of tetrodotoxin-producing bacteria have been found in puffer fish, the blue-ringed octopus, and certain small and other animals. It appears that the animals become toxic by sequestering the bacterially produced toxin in their tissues. (New York Times Science, December, 2009) The exact origin of tetrodotoxin in the food chain remains unclear. The only common dominator seems to be that tetrodotoxin producing animals are closely related to an aquatic system and the bacteria that commonly inhabit the aquatic system. (MDPI Marine Drugs, May 2008) The toxic dose is not clear because puffer fish have different concentrations of tetrodotoxin. A dose of 1-2 mg of purified toxin can be lethal. Reported cases from the Centers for Disease Control and Prevention (CDC) have documented toxicity with ingestion as little as 1.4 ounces of puffer fish. (Medscape CDC Commentary Series, October, 2009) In contrast, the botulinum toxin (Clostridium botulinum) is reported to be the most toxic substance known. If evenly dispersed for inhalation, 1 gram of pure (botulinum) toxin is sufficient to kill 1 million people. (Ryan Glarum, 2008, p. 65) Tetrodotoxin is a neurotoxin. Neurotoxin is a toxin that acts specifically on nerve cells of the nervous system, typically by interacting with membrane proteins and especially ion channels. (Knowledgerush, n.d.) Tetrodotoxin binds to the sodium channel of the nerve preventing the passage of sodium ions through the cell membrane and therefore (passage) of the nerve impulse. (CBWinfo.com, 1999) Many of the venoms and other toxins that organisms use in defense against vertebrates are neurotoxins. A common effect is paralysis, which typically onsets extremely rapidly. (Knowledgerush) The first symptom of (tetrodotoxin) intoxication is a slight numbness of the lips and tongue, appearing between 20 minutes to three hours after eating poisonous puffer fish,. The next symptom is increasing paraesthesia in the face and extremities, which may be followed by sensations of lightness or floating. Headache, epigastric pain, nausea, diarrhea, and/or vomiting may occur. Occasionally, some reeling or difficulty in walking may occur. The second state of the intoxication is increasing paralysis. Many victims are unable to move; even sitting may be difficult. There is increasing respiratory distress. Speech is affected, and the victim usually exhibits dyspnea, cyanosis, and hypotension. Paralysis increases and convulsions, mental impairment, and cardiac arrhythmia may occur. The victim, although completely paralyzed, may be conscious and in some cases completely lucid until shortly before death. Death usually occurs with in 4 to 6 hours, with a known range of about 20 minutes to 8 hours. (U.S. Department of Health and Human Services; FDA U.S. Food Drug Administration, n.d.) No specific antidote has been tested in humans. No drug has been shown to reverse the effects of tetrodotoxin poisoning. Treatment is symptomatic. Specific drug efficacy has only been documented anecdotally. (Medscape CDC Commentary Series, October 2009) Animal studies using monoclonal antibodies against TTX have been done. Monoclonal antibodies were shown to e life saving in mice treated both before and after the ingestion of a lethal dose of TTX. Further studies are needed to document the efficacy in humans. In another study using guinea pigs intoxicated with tetrodotoxin, 4-aminopyridine (a potassium channel blocker) showed dramatic improvement in respiratory, cardiac, and CNS status occurred after administration of the drug. No human studies of this drug for use in tetrodotoxin poisoning are in progress. (Medscape CDC Commentary Series, October 2009) No specific laboratory test confirms tetrodotoxin ingestion exits; thus dietary history is key for diagnosis. Tetrodotoxin poisoning can be misdiagnosed as one of many differential diagnoses including: gastroenteritis, Guillain-Barre Syndrome, 1st, 2nd and 3rd degree heart blockage, hypocalcemia, Lambert-Eaton Myasthenic Syndrome, myasthenia gravis, octopus envenomations, and ciguatera, scombroid and shellfish toxicity. Since tetrodotoxin is produced from bacteria, there is a risk that the toxin could be manufactured on a significant scale by fermentation. (CBWinfo.com, 1999) Tetrodotoxin is a colorless crystalline solid that darkens when heated about 428à ° F or 220à ° C. (CDC National Institute for Occupational Safety and Health, n.d.) Relatively is little is known about tetrodotoxin as a possible toxin weapon although the Japanese did some work its weaponization in Unite 731 during World war II. It is included on the Australia Group lists by reason of its toxicity. It is not known to be made in large quantities that could be used in weapons and little or nothing is know about its inhalation toxicity. (CBWinfo.com, 1999) ( NOTE: The Australia Group (AG) is an informal forum of countries which, through the harmonization of export controls, seeks to ensure that exports do not contribute to the development of chemical or biological weapons. Coordination of national export control measures assists Australia Group participants to fulfill their obligations under the Chemical Weapons Convention and the Biological and Toxin Weapons Convention to the fullest extent possible.) (The Australia Group, n.d.) The National Institute for Occupational Safety and Health (NIOSH) offers insight into the various methods tetrodotoxin could be disseminated and the feasibility of each method. For example, dissemination through indoor air, outdoor air or water is extremely unlikely because the source of the toxin is living organisms and to manufacture tetrodotoxin in appreciable quantities is extremely difficult. And, since tetrodotoxin is unlikely to be disseminated in the air, it is also unlikely to be disseminated through agricultural products. Ingestion does seem the most likely source of dissemination. Exposure to tetrodotoxin usually occurs through eating improperly prepared fish or possibly through contamination of other food products. (CDC National Institute for Occupational Safety and Health, n.d.) According to NIOSH, there is no antidote for tetrodotoxin toxicity and initial treatment is primarily supportive. In 2007 two individuals developed symptoms consistent with tetrodotoxin poisoning after ingesting home-cooked puffer fish purchased in Chicago. Both the retailer and supplier claimed the product was monkfish. High levels of tetrodotoxin were detected in the remains of the ingested meal and fish retrieved from the contaminated shipment. This case of tetrodotoxin poisoning highlights the need for continued stringent regulation of puffer fish importation by the U.S. Food and Drug Administration, education of the public regarding the dangers of puffer fish consumption, and raising awareness among medical providers of the diagnosis and management of foodborne toxin ingestions and the need for reporting to public health agencies. (PubMed U.S. National Library of Medicine National Institute of Health, 2009) Currently tetrodotoxin is manufactured by several specialized biotech companies. CHEMTE Biotech Company, LTD located in Nanjing, Jiangsu, China specializes in the manufacture of tetrodotoxin. According to CHEMTE Biotechs website, after ten years research and development, we have achieved extensive isolation and purification of TTX based on the abundant resource in our area. We founded the TTX production base in the world with annual product (sic) is more than 1000g. (CHEMTE Biotech Company, Ltd., n.d.) Through the use of their technology process CHEMTE has raised production rate and product quality of TTX up to the worlds highest level. CHEMTE boasts that their customers in many countries find their purity is higher than their own pure products. Currently in the European market, TTX from CHEMTE is sold as the standard product. (CHEMTE Biotech Company, Ltd., n.d.) The China Kantte Bio-Chemical company located in Shanghai, China produces tetrodotoxin extracted from puffer fish in large scale, and purified close to 100% by high-performance liquid chromatograph (HPLC) and capillary electrophoresis. (China Kantte Bio-Chemical, n.d.) While it is possible to procure TTX for research as a potential pain therapeutic and medicine for opium withdrawal symptoms, its purchase is limited to researchers and scientistsà ¢Ã¢â ¬Ã ¦.just ask Edward F. Bachner IV of Lake Hills, Illinois. On August 26, 2008 a federal grand jury in Rockford, Illinois returned a ten-count indictment charging him with unlawfully acquiring and possessing tetrodotoxin, on five separate occasions between November 7, 2006 and June 30, 2008. Five of the counts allege that on five separate occasions, Bachner acquired tetrodotoxin in order to use it as a weapon. Bachner possessed tetrodotoxin in a quantity that was not reasonable justified by a prophylactic, protective, bona fide research, or other peaceful purpose. If convicted of acquiring TTX to use as a weapon, Bachner could be sentenced to a maximum penalty of life imprisonment. (U.S. Department of Justice, 2008) As a fun aside, during my research I came across an interesting article about the use of tetrodotoxin and folklore surrounding creation of zombies. In eight samples of zombie powder collected from four regions of Haiti all appeared to have four ingredients in common: 1) one or more species of puffer fish which contained tetrodotoxin, 2) a toxic marine frog, 3) a hyla tree frog which secretes an irritating substance, and 4) human remains. (Strayer University, n.d.) According to some theories a person poisoned with Haitian zombie powder regains consciousness either while in the coffin or shortly after being removed from it and therefore, think they have died and are now a zombie. (How Stuff Works, n.d.) When analyzing an agent as a potential biological agent for use as a weapon of bioterrorism one must examine certain attributes as they apply to that specific agent. Some of these attributes include ease of dissemination, route of entry, morbidity, mortality, infectivity, potential for contagion, potential for panic and social disturbance, and the impact on public health and public health preparedness. The most efficient route of entry for tetrodotoxin would be ingestion either through consumption of the toxin itself or the consumption of other food products tainted with tetrodotoxin. Because ingestion is the favored route of entry, tetrodotoxin does not lend itself for use as a weapon that is easily disseminated or for use as a bioterrorism weapon. Tetrodotoxin does have some potential use as a target specific biological weapon. Bioterrorists could use tetrodotoxin for targeted victims, such as political figures, world leaders or small contingents of military forces. Even for use on targeted specific victims tetrodotoxin is not be easily disseminated. Tetrodotoxin poisoning would require the introduction of the toxin directly into a food or liquid source ingested by the target. Ingestion as a route of entry makes tetrodotoxin not easily disseminated. Morbidity rates are 100% for tetrodotoxin poisoning; rarely will ingestion of tetrodotoxin contaminated food leave the victim unscathed as evidenced by the number of fugu poisoning cases recorded in Japan each year. Tetrodotoxin with its high morbidity rate could be considered as a weapon for bioterrorism. Infectivity rates for tetrodotoxin are 100%. Another fact influencing the high morbidity rate of tetrodotoxin poisoning is the possibility it can easily be mistaken for one of many differential diagnoses. Patients presenting with tetrodotoxin poisoning could easily be misdiagnosed especially if a valid dietary history is unavailable or overlooked. Mortality rates for tetrodotoxin are difficult to establish; anecdotal reports suggest 50-60% mortality, even with good supportive care. One report suggests that prognosis is good if the patient survives the first 24 hours. (Medscape CDC Commentary Series, October 2009) The same cannot be said for biological agents like plague. In the pneumonic form plague is almost 100% fatal without immediate medical attention. (Ryan Glarum, 2008) A biological weapon with only a possible 50-60% mortality rate would probably not be perceived as an effective weapon of bioterrorism. Unlike some other biological agents that lend themselves to inhalation or person-to-person transmission, tetrodotoxin poisoning is transmitted only through ingestion of the toxin. It does not have the potential as a weapon of bioterrorism because transmission is limited to persons ingesting the toxin. Tetrodotoxin poisoning offers no potential threat for contagion in terms of an epidemic or pandemic. The bacteria are contained within the host organism. Tetrodotoxin poisoning could certainly create panic and social disturbance, especially if the targeted victims were persons of political or military importance. There could also be public panic caused by the concern as to the nature, origin and location of the toxin. To be considered as a potential weapon of bioterrorism the biological agent would need to: 1) be easily disseminated or transmitted, 2) cause high mortality, 3) severely affect the public health, 4) cause public panic and social disruption, and 5) require special action for public health preparedness. Overall, while tetrodotoxin is a lethal neurotoxin with: 1) a high level of morbidity, 2) moderate level of mortality, 3) a difficult dissemination method, 4) ingestion as the route of entry, 5) no transmission qualities, 6) no likelihood of contagion and 7) unlikely to cause panic or social disruption, in my opinion it would not be useful as a biological weapon of mass destruction. In my opinion tetrodotoxin has some modest potential as a limited bioterrorism agent in special circumstances. Tetrodotoxin does not meet all the necessary criteria to be considered as a biological agent capable of causing severe damage to the health and safety of the public.
Wednesday, October 2, 2019
BATTLE OF NEW ORLEANS :: essays research papers
The battle of New Orleans was a significant battle in the war of 1812. It was a crushing defeat for the British, increased patriotism, and Andrew Jackson emerged an American hero. The United States acquired the Louisiana Territory from France in 1803, thereby gaining control of the Mississippi River, and its watershed at the golf of Mexico. The U.S. government realized how important this was and its potential of becoming a great trading post. By 1812 this area called New Orleans grew as expected in size and importance. In peace it was a commercial outlet and trading center of the western United States. à à à à à The British chose to attack the Americans from the north by way of Isle aux Pois in the mouth of the Pearl River because this was the only only stable water they had found that ships could ride and anchor. When hearing that the british where coming this way, Lieutenant Thomas Ap Catesby Jones and his five gunboats went to try and Barackade the Rigolets trying to make sure they wouldnââ¬â¢t enter. His 185 men and 23 guns awaited the British. At 10:30 on December 14th 1814 three columns of British ships, 42 to 45, armed with 43 guns and 1,200 under the command of Captain Lockyer met the American blockade. Fierce fighting began and the British had finally captured the five American boats. Losses were 17 British and 6 Americans killed, 77 British and 35 Americans wounded. This gave Gerneral Andrew Jackson six days more to improve his defenses. The British at the very beginning of the war had demolished almost all of Jacksons sea power. Jackson only had the Carolina , Louisiana, and one gunboat left. à à à à à When Jackson heard of the attack on Jonesââ¬â¢ ships on December 15 he issued crises orders to forces nearby. One General by the name of Coffee received orders from Jackson stating ââ¬Å"You must not sleep until you reach me or arrive withink striking distance.â⬠The next day Jackson placed New Orleans under Martial Law. When General Coffee received his orders he immediately gathered his 1250 men and where off to help Jackson. Each man brought with him a hunting knife and long rifle. The Tenessee brigade commanded by Major General William Caroll arrived on 21st December. Only one in ten of them had a firearm.
Free College Admissions Essays - A Loss of Innocence :: College Admissions Essays
A Loss of Innocence The United States of America lost its innocence on September 11, 2001. No longer are the vicious attacks on democracy in some far away country; they are now in our own backyard. President Bush said it best, "freedom itself was attacked by a faceless coward..." but now we know the name of that face. For many of us, this is the first time we have experienced what others around the world live with daily. As young people, we can have a profound impact on the future. We can start at this level by supporting our country and the ideals it holds dear. We must remember that the very privilege of an education is one that those who attacked us plainly detest. In fact, it is illegal for women in that country to pursue an education at all. Every step we achieve in the learning process is in defiance to those who keep their citizens ignorant. As students and citizens, we must realize that the power of education comes with a responsibility: to help people of all backgrounds understand that if we are to make any progress as a society, we cannot tolerate terrorism anywhere in our world. However, we must be careful not to express our outrage irrationally against people who had nothing to do with that evil act. One motive for the terrorist attack on our country was contempt for the freedom that allows America to tolerate those who hold different beliefs. Our future belongs to those who stand up and fight for what they believe in. As a nation, we are now at the crossroads: we can choose to allow those with evil intentions to have the loudest voices or we can stand together with one voice. It has been said, "All that evil needs to succeed is for
Tuesday, October 1, 2019
Helmet to Helmet Rule Change the Game
The recent story in the NFL is helmet to helmet hits on defenseless player. The league committees are trying to make the league safer for the player to reduce injuries. The NFL Commissioner is not doing a good job protecting the players because concussion and major head damage keep happening. The Commissioners idea is to penalize by a 15 yards penalty on the field against their team, but also charged significant fines toward the player who commit the penalty. (Benavent) By fining the players the league is changing the speed of the game, the hard hitting and the fun of game.NFL Commissioner Robert Goodell stated: Strategy, strength and speed are what make the game great. We donââ¬â¢t want to take physical contact out of the game. But we must ensure that players follow rules designed to reduce the risk of injury. Enforcing rules on illegal hits to the head with fines and suspensions has changed tackling for the better. Players and coaches have adjusted. They always do. We now see fe wer dangerous hits to the head and noticeable changes in the way the game is being played. Thatââ¬â¢s true the league is safe but fining player is not going to fix the problem.The fact is that when you are tackling you are using your head which is a fundamental football. A tackle is when a player using a great amount of force to bring a ball carrier down. Further, itââ¬â¢s when a defender at lower leverage and strikes a ball carrier with his head across the ball carrier body with his arms wraped around him bring him down. Letââ¬â¢s say that the ball carrier does the same thing lowering his head trying to avoid the hit and now the defender is call for helmet to helmet hit. In the act helmets would hit together. Itââ¬â¢s not unavoidable and certainly not intentional.I think that the NFL commissioner wants to encourage players to hit low toward the knees where the ball carrier has no protection. The result will in tearing ACLââ¬â¢s and other ligaments that end playersâ⠬⢠season and possibly careers. During this season there would be a lot of flags thrown during the game causing the game to be longer. But thatââ¬â¢s not the main idea it is how to determine which violent hit is considered a penalty and a fine. Some of the violent hits are not called and some hits are called. The league needs to figure out which are and which are not.Most of the time these hard helmet hits happen when a receiver goes across the middle and a defender is attempting to stop the receiver from catching the ball. To clarify: Forcibly hitting the defenseless playerââ¬â¢s head or neck area with the helmet, facemask, forearm, or shoulder, regardless of whether the defensive player also use his arms to tackle the defenseless player by encircling or grasping him; and lowering the head and making forcible contact with the top, crown or forehead ââ¬Å"hairlineâ⬠parts of the helmet against any part of the defenseless playerââ¬â¢s body. Lapsncaps) There are a lo t of conversely between NFL Commissioner Goodell and players because the fact that they have to change their playing style and adjust to the new league safety rules. I think that itââ¬â¢s hard to adjust because football is a violent sport and tackles require force. I understand there trying to protect players, but there inconsistent and making it into a sissy league. Tackling is part of football. When a defender tackles a ball carrier helmet to helmet hit well happen.Itââ¬â¢s not unavoidable and certainly no intentional. This sport is completive each team want a victory however in a situation when it really counts and a receiver attempts to catch the ball the defender would must likely hit the receiver to knocked to ball lose. But if the defender ââ¬Å"forcibly hit the defenseless playerââ¬â¢s head or neck area, lowering his head to any part of the defenseless playerââ¬â¢s body is a penalty and fined thousands. The NFL wants to stop the concussion and prevent players wi th long term health problems.
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